Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a Ghk Cu Tolerance Desensitization Effectiveness Loss Intermediate Cu(II) Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction Inorganic Chemistry TOLERANCE & TACHYPHYLAXIS Tachyphylaxis an overview ScienceDirect Topics Factors Responsible Or Causes of Tolerance and Tachyphylaxis Of Drugs in Pharmaology