Safe IM Injection Site Intramuscular injection should always be given in the **upper outer quadrant of the gluteal region** to prevent sciatic nerve injury. Key nursing points: Upper outer quadrant = Hiya. I have a question. Is a B12 injection basically a dose of iron? How to Use These 4 IM Injection Spots Safely B12 vitamin Store How to Give an Intramuscular Injection of Vitamin B12 Best Vitamin B12 Injection Sites: Where to Inject B12 PA Relief How to Give Yourself Intramuscular (IM) Injections Patients & Families UW Health