Oral Mucosal Melanosis IntechOpen Spotty lips. These are labial melanotic macules, kinda like freckles on the lips. They are mostly due to age and sun exposure, but sometimes they run in families and are associated with Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Oral melanotic macule" Mucosal melanocytic macules Labial Melanotic Macules in Atopic Dermatitis: An Observational Study Semantic Scholar