Can you donate blood if you smoke? We all know smoking and vaping isn't great for your health. But it doesn't stop you from being a blood or plasma donor. Just make sure to wait one hour after donating Heart disease doesn't have to keep you from donating blood American Heart Association Are vape pens, or e cigarettes, ever the better option? Ohio State Health & Discovery Cannabis Use and Blood Donation: Unmasking the Truth Smoking and vaping don't affect your eligibility to donate. Become a donor and give life today.